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Extent, causes, and consequences of small RNA expression variation in human adipose tissue.

Abstract:

Small RNAs are functional molecules that modulate mRNA transcripts and have been implicated in the aetiology of several common diseases. However, little is known about the extent of their variability within the human population. Here, we characterise the extent, causes, and effects of naturally occurring variation in expression and sequence of small RNAs from adipose tissue in relation to genotype, gene expression, and metabolic traits in the MuTHER reference cohort. We profiled the expressio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1002704

Authors


Hedman, Å More by this author
Keildson, S More by this author
Knights, AJ More by this author
Abreu-Goodger, C More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
8
Issue:
5
Pages:
e1002704
Publication date:
2012
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:cb0eda14-2813-4aa4-ad11-c97f5429446d
Source identifiers:
332785
Local pid:
pubs:332785

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