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Journal article

The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcome.

Abstract:

Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. It has been observed that axonal loss in MS is significant and that irreversible clinical disability relates to such axonal loss. The clinical similarities between Hereditary Spastic Paraplegia (HSP) and progressive MS, along with their analogous profiles of axonal loss in the long tracts, make the genes known to cause HSP biologically relevant candidates ...

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Publication status:
Published

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Publisher copy:
10.1007/s00415-006-0505-4

Authors


DeLuca, GC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
Dyment, DA More by this author
Herrera, BM More by this author
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Journal:
Journal of neurology
Volume:
254
Issue:
9
Pages:
1221-1226
Publication date:
2007-09-05
DOI:
EISSN:
1432-1459
ISSN:
0340-5354
URN:
uuid:cb0e51d9-f852-4b08-9172-ba50c21a8ab0
Source identifiers:
33810
Local pid:
pubs:33810

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