Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin.

Journal article

Recent studies have indicated that regulatory mechanisms underlying the oxygen-dependent expression of the haematopoietic growth factor erythropoietin are widely operative in non-erythropoietin-producing cells and are involved in the regulation of other genes. An important characteristic of this system is that the inducible response to hypoxia is mimicked by exposure to particular transition metals such as cobaltous ions, and by iron chelation. We have investigated the extent of operation of ...

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Authors: Ebert, B; Gleadle, J; O'Rourke, J; Bartlett, S; Poulton, J

• Publication status: Published
• Journal: Biochemical journal
• Volume: 313 ( Pt 3)
• Pages: 809-814
• Publication date: 1996-02-01
• EISSN: 1470-8728
• ISSN: 0264-6021
• Language: English
• Keywords: Cell Hypoxia; Erythropoietin; Oligonucleotide Probes; Gene Expression Regulation; Cobalt; Molecular Sequence Data; Energy Metabolism; Cell Line; Mitochondria; RNA, Messenger; Deferoxamine; Monosaccharide Transport Proteins; Isoenzymes; Glycolysis; Humans; Siderophores; Hela Cells; Base Sequence