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Capabilities and limitations of tissue size control through passive mechanical forces

Abstract:

Embryogenesis is an extraordinarily robust process, exhibiting the ability to control tissue size and repair patterning defects in the face of environmental and genetic perturbations. The size and shape of a developing tissue is a function of the number and size of its constituent cells as well as their geometric packing. How these cellular properties are coordinated at the tissue level to ensure developmental robustness remains a mystery; understanding this process requires studying multiple...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1004679

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Computational Biology Journal website
Volume:
11
Issue:
12
Pages:
e1004679
Publication date:
2015-12-29
Acceptance date:
2015-11-24
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Language:
English
Keywords:
Pubs id:
pubs:585931
UUID:
uuid:cb05096f-5dac-4748-9137-39543f42f327
Local pid:
pubs:585931
Source identifiers:
585931
Deposit date:
2016-05-11

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