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Journal article

CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus.

Abstract:

In order to test the hypothesis that CD8+ cytotoxic T lymphocytes mediate protection against acute superinfection, we depleted >99% of CD8+ lymphocytes in live attenuated simian immunodeficiency virus macC8 (SIVmacC8) vaccinees from the onset of vaccination, maintained that depletion for 20 days, and then challenged with pathogenic, wild-type SIVmacJ5. Vaccinees received 5 mg per kg of humanized anti-CD8 monoclonal antibody (MAb) 1 h before inoculation, followed by the same dose again on d...

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Publication status:
Published

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Authors


Stebbings, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Journal of virology
Volume:
79
Issue:
19
Pages:
12264-12272
Publication date:
2005-10-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:cb024192-91ac-4a7f-acca-ef03e0639aee
Source identifiers:
26952
Local pid:
pubs:26952

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