- Abstract:
-
In order to test the hypothesis that CD8+ cytotoxic T lymphocytes mediate protection against acute superinfection, we depleted >99% of CD8+ lymphocytes in live attenuated simian immunodeficiency virus macC8 (SIVmacC8) vaccinees from the onset of vaccination, maintained that depletion for 20 days, and then challenged with pathogenic, wild-type SIVmacJ5. Vaccinees received 5 mg per kg of humanized anti-CD8 monoclonal antibody (MAb) 1 h before inoculation, followed by the same dose again on d...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/jvi.79.19.12264-12272.2005
-
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- Journal:
- Journal of virology
- Volume:
- 79
- Issue:
- 19
- Pages:
- 12264-12272
- Publication date:
- 2005-10-05
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- URN:
-
uuid:cb024192-91ac-4a7f-acca-ef03e0639aee
- Source identifiers:
-
26952
- Local pid:
- pubs:26952
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus.
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