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Journal article

External validation of the bilirubin-atazanavir nomogram for assessment of atazanavir plasma exposure in HIV-1-infected patients.

Abstract:

Atazanavir increases plasma bilirubin levels in a concentration-dependent manner. Due to less costly and readily available assays, bilirubin has been proposed as a marker of atazanavir exposure. In this work, a previously developed nomogram for detection of suboptimal atazanavir exposure is validated against external patient populations. The bilirubin nomogram was validated against 311 matching bilirubin and atazanavir samples from 166 HIV-1-infected Norwegian, French, and Italian patients on...

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Publication status:
Published

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Publisher copy:
10.1208/s12248-012-9440-8

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Journal:
AAPS journal
Volume:
15
Issue:
2
Pages:
308-315
Publication date:
2013-04-01
DOI:
EISSN:
1550-7416
ISSN:
1550-7416
Source identifiers:
445525

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