Biochemical study of the interactions between cohesin and DNA

Thesis

Cohesin is a ring like SMC-kleisin complex (S-K ring) that mediates DNA interactions between chromosomes. It is responsible for the phenomenon of sister chromatid cohesion (SCC) and ensures the faithful segregation of chromosomes during mitosis. Cohesin also mediates interactions within chromosomes by organising DNA into loops in both interphase and mitosis. SCC is thought to be mediated by co-entrapment of sister DNAs within a single cohesin S-K ring. Cohesin will also entrap individual c...

Expand abstract

Authors: Collier, JE

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Biochemistry; Chromosome biology; Cohesin
• Subjects: Biochemistry; Chromosome biology