Variation at the IRF2 gene and susceptibility to psoriasis in chromosome 4q-linked families.

Parkinson, J; Charon, C; Baker, BS; Powles, AV; Rogers, S; Caird, A; Smedley, D; Halford, S; Fry, L; McCarthy, MI

Abstract:

Evidence, largely from Irish pedigrees, indicates that a susceptibility locus for psoriasis maps to chromosome 4q. The gene encoding interferon regulatory factor-2 (IRF-2) maps to this region, and, as mice lacking IRF-2 exhibit a dermatologic phenotype resembling many aspects of human psoriasis, IRF-2 represents an attractive positional candidate. We set out to establish whether variation in IRF-2 sequence or expression was related to the development of psoriasis. First, the promoter, coding,...

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APA Style

Parkinson, J., Charon, C., Baker, B. S., Powles, A. V., Rogers, S., Caird, A., Smedley, D., Halford, S., Fry, L., & McCarthy, M. I. (2004). Variation at the IRF2 gene and susceptibility to psoriasis in chromosome 4q-linked families. The Journal of Investigative Dermatology, 122(3), 640–643.

MLA Style

Parkinson, J., et al. “Variation at the IRF2 Gene and Susceptibility to Psoriasis in Chromosome 4q-Linked Families.” The Journal of Investigative Dermatology, vol. 122, no. 3, The Journal of investigative dermatology, 2004, pp. 640–43.

Chicago Style

Parkinson, J, C Charon, BS Baker, AV Powles, S Rogers, A Caird, D Smedley, S Halford, L Fry, and MI McCarthy. 2004. “Variation at the IRF2 Gene and Susceptibility to Psoriasis in Chromosome 4q-Linked Families.” The Journal of Investigative Dermatology 122 (3): 640–43.
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