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Variation at the IRF2 gene and susceptibility to psoriasis in chromosome 4q-linked families.

Abstract:

Evidence, largely from Irish pedigrees, indicates that a susceptibility locus for psoriasis maps to chromosome 4q. The gene encoding interferon regulatory factor-2 (IRF-2) maps to this region, and, as mice lacking IRF-2 exhibit a dermatologic phenotype resembling many aspects of human psoriasis, IRF-2 represents an attractive positional candidate. We set out to establish whether variation in IRF-2 sequence or expression was related to the development of psoriasis. First, the promoter, coding,...

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Publication status:
Published

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Authors


Parkinson, J More by this author
Powles, AV More by this author
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Journal:
The Journal of investigative dermatology
Volume:
122
Issue:
3
Pages:
640-643
Publication date:
2004-03-05
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
URN:
uuid:cafbca93-8084-4a8f-8dea-3616455df80a
Source identifiers:
8679
Local pid:
pubs:8679

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