Journal article
Variation at the IRF2 gene and susceptibility to psoriasis in chromosome 4q-linked families.
- Abstract:
-
Evidence, largely from Irish pedigrees, indicates that a susceptibility locus for psoriasis maps to chromosome 4q. The gene encoding interferon regulatory factor-2 (IRF-2) maps to this region, and, as mice lacking IRF-2 exhibit a dermatologic phenotype resembling many aspects of human psoriasis, IRF-2 represents an attractive positional candidate. We set out to establish whether variation in IRF-2 sequence or expression was related to the development of psoriasis. First, the promoter, coding,...
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- Publication status:
- Published
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- Publisher copy:
- 10.1046/j.0022-202x.2004.22135.x
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Bibliographic Details
- Journal:
- The Journal of investigative dermatology
- Volume:
- 122
- Issue:
- 3
- Pages:
- 640-643
- Publication date:
- 2004-03-05
- DOI:
- EISSN:
-
1523-1747
- ISSN:
-
0022-202X
- URN:
-
uuid:cafbca93-8084-4a8f-8dea-3616455df80a
- Source identifiers:
-
8679
- Local pid:
- pubs:8679
Item Description
Terms of use
- Copyright date:
- 2004
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