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Erythrocyte sequestration and anemia in severe falciparum malaria. Analysis of acute changes in venous hematocrit using a simple mathematical model.

Abstract:

Microvascular erythrocyte sequestration, the characteristic pathological feature of falciparum malaria, was evaluated using a mathematical model in 46 patients with severe infections. From admission radioisotopic circulating red cell volumes and simultaneous venous hematocrits, the model-derived sequestrum hematocrit (mean [95% confidence limits]: 0.70 [0.43-0.97], n = 29) was twice that of peripheral blood (0.33 [0.30-0.36]). Serial reticulocyte and radiolabeled erythrocyte counts indicated ...

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Publication status:
Published

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Publisher copy:
10.1172/jci114776

Authors


Krishna, S More by this author
Looareesuwan, S More by this author
Supanaranond, W More by this author
Pukrittayakamee, S More by this author
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Journal:
The Journal of clinical investigation
Volume:
86
Issue:
3
Pages:
793-800
Publication date:
1990-09-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:caf767b0-5f29-42ac-9683-3a24ff1a05ac
Source identifiers:
43480
Local pid:
pubs:43480

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