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pH dependence of listeriolysin O aggregation and pore-forming ability.

Abstract:

Listeriolysin O (LLO) is the major factor implicated in the escape of Listeria monocytogenes from the phagolysosome. It is the only representative of cholesterol-dependent cytolysins that exhibits pH-dependent activity. Despite intense studies of LLO pH-dependence, this feature of the toxin still remains incompletely explained. Here we used fluorescence and CD spectroscopy to show that the structure of LLO is not detectably affected by pH at room temperature. We observed slightly altered haem...

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Publication status:
Published

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Journal:
FEBS journal More from this journal
Volume:
279
Issue:
1
Pages:
126-141
Publication date:
2012-01-01
DOI:
EISSN:
1742-4658
ISSN:
1742-464X

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