Synthesis and properties of DNA-PNA chimeric oligomers.

Journal article

Adenine, thymine and cytosine PNA monomers have been prepared using 3-amino-1,2-propanediol as a starting material. The benzoyl group was used to protect the exocyclic amines of the heterocyclic bases of A and C PNA monomers and the backbone primary amine was protected with the monomethoxytrityl group. The thymine and cytosine PNA monomers were used in conjunction with standard DNA synthesis monomers to produce chimeric PNA DNA (PDC) oligomers. Ultraviolet melting studies confirmed that these...

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Authors: Finn, P; Gibson, N; Fallon, R; Hamilton, A; Brown, T

• Publication status: Published
• Journal: Nucleic acids research
• Volume: 24
• Issue: 17
• Pages: 3357-3363
• Publication date: 1996-09-01
• DOI: 10.1093/nar/24.17.3357
• EISSN: 1362-4962
• ISSN: 0305-1048
• Language: English
• Keywords: Nucleic Acid Denaturation; Propanolamines; Chemistry, Organic; Oligodeoxyribonucleotides; Peptides; Propylene Glycols