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Synthesis and properties of DNA-PNA chimeric oligomers.

Abstract:

Adenine, thymine and cytosine PNA monomers have been prepared using 3-amino-1,2-propanediol as a starting material. The benzoyl group was used to protect the exocyclic amines of the heterocyclic bases of A and C PNA monomers and the backbone primary amine was protected with the monomethoxytrityl group. The thymine and cytosine PNA monomers were used in conjunction with standard DNA synthesis monomers to produce chimeric PNA DNA (PDC) oligomers. Ultraviolet melting studies confirmed that these...

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Publication status:
Published

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Publisher copy:
10.1093/nar/24.17.3357

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Nucleic acids research More from this journal
Volume:
24
Issue:
17
Pages:
3357-3363
Publication date:
1996-09-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Pubs id:
pubs:400079
UUID:
uuid:caef259f-712f-4d0d-9375-a2fa1e7a7308
Local pid:
pubs:400079
Source identifiers:
400079
Deposit date:
2013-11-16

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