Back to Search
Thesis icon

Thesis

Design, synthesis and properties of multivalent DNA nanomaterials for cancer diagnostics and therapeutics

Abstract:

Aptamer-functionalised DNA nanostructures have been developed as drug nanocarriers for targeted cancer therapy and other in vivo applications. Among them, hierarchical DNA nanoflowers (DNA-NFs) with densely packed DNA that can self-assemble using rolling circle amplification (RCA) hold promise for cancer therapy. To expand the functionality of DNA-NFs, the inorganic core of the nanoflowers was chemically modified through substitution of Mg2+ with either Mn2+ or Co

Expand abstract

Actions

  • Cite

  • Print

Access Document

Files:

Authors

More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
UUID:
uuid:caecf6d8-2972-4876-8197-53e5f676d712
Deposit date:
2020-02-11

Terms of use

Views and Downloads





If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP