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An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Abstract:

Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate cilia: poorly understood organelles, where defects cause genetic diseases. Two hundred and seventeen tagged human ciliary proteins create a final landscape of 1,319 proteins, 4,905 interactions and 52 complexes. Reverse tagging, repetition of purifications and statistical analyses, produce a high-resolution network that reveals organel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms11491

Authors


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Role:
Author
ORCID:
0000-0002-0658-4399
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Name:
National Institutes of Health
Grant:
EY021872
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Name:
Seventh Framework Programme
Grant:
278568
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Name:
Tistou and Charlotte Kerstan Stiftung
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Volume:
7
Pages:
11491
Publication date:
2016-05-13
Acceptance date:
2016-04-01
DOI:
ISSN:
2041-1723
Keywords:
Pubs id:
pubs:844994
UUID:
uuid:caec74e1-9769-4049-8f27-7acb51d09a31
Local pid:
pubs:844994
Source identifiers:
844994
Deposit date:
2018-05-14

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