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Journal article

Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1.

Abstract:

The TLRs play a key role in host defense against infection and injury, and mounting evidence suggests that these receptors may also play a role in diseases such autoimmunity, atherosclerosis, and cancer. Activation of TLRs on macrophages results in the production of multiple soluble mediators including the key inflammatory cytokines, TNF and IL-6. Thus, the intracellular signaling mechanism by which TLRs signal is a subject of great interest. As well as activating the NF-κB and MAPK pathways,...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1100967

Authors


Smolinska, MJ More by this author
Urbaniak, AM More by this author
Horwood, NJ More by this author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
187
Issue:
11
Pages:
6043-6051
Publication date:
2011-12-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:cae67756-80a3-4997-b9d5-d987f4d99d5d
Source identifiers:
223546
Local pid:
pubs:223546

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