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Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer.

Abstract:

Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, histone acetylation readers such as bromodomain-containing protein 4 (BRD4) have been shown to associate with these TFs and contribute to aggressive cancers including prostate cancer (PC). Here, we show that chromatin accessibility defines castration-resistant prostate cancer (CRPC). We show that the deregulation of androgen receptor (AR) expression is a driv...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


More from this funder
Name:
Structural Genetics Consortium
Grant:
1097737
More from this funder
Name:
Wellcome Trust
Grant:
MC_PC_13073
More from this funder
Name:
Cancer Foundation Finland sr
Grant:
150112
More from this funder
Name:
Medical Research Council
Grant:
MC_PC_13073
More from this funder
Name:
Norwegian Cancer Society
Grant:
4521627
Publisher:
Elsevier
Journal:
Cell Reports More from this journal
Volume:
19
Issue:
10
Pages:
2045-2059
Publication date:
2017-06-01
Acceptance date:
2017-05-12
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pmid:
28591577
Language:
English
Keywords:
Pubs id:
pubs:700740
UUID:
uuid:cae2c884-bfbb-4311-ac61-4228a3374e1a
Local pid:
pubs:700740
Source identifiers:
700740
Deposit date:
2018-01-08

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