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Thesis

Identification and characterisation of suppressors of synthetic lethality resulting from loss of SETD2 and WEE1

Abstract:

Our lab has recently identified a conserved synthetic lethality between loss of SETD2-dependent H3K36 trimethylation and inhibition of WEE1 kinase (Pfister et al., 2015). In order to explore the possible mechanisms of resistance to WEE1 inhibitor-treatment in H3K36me3-deficient cells, a yeast genetic screen was performed to isolate mutants that suppressed the set2Δ wee1-50 temperature sensitivity. Whole-genome sequencing of 23 spontaneous suppressor mutants revealed mutations in e...

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Division:
MSD
Department:
Oncology
Role:
Author

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Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
UUID:
uuid:cadc1392-a031-496e-8ad1-def942ab4893
Deposit date:
2018-03-17

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