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TSG‐6 is weakly chondroprotective in murine OA but does not account for FGF2‐mediated joint protection

Abstract:

Objective Tumor necrosis factor α–stimulated gene 6 (TSG‐6) is an anti‐inflammatory protein highly expressed in osteoarthritis (OA), but its influence on the course of OA is unknown. Methods Cartilage injury was assessed by murine hip avulsion or by recutting rested explants. Forty‐two previously validated injury genes were quantified by real‐time polymerase chain reaction in whole joints following destabilization of the medial meniscus (DMM) (6 hours and 7 days). Joint pathology was assesse...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/acr2.11176

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Role:
Author
ORCID:
0000-0001-9594-7085
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Kennedy Trust for Rheumatology Research More from this funder
Publisher:
Wiley Publisher's website
Journal:
ACR Open Rheumatology Journal website
Volume:
2
Issue:
10
Pages:
605-615
Place of publication:
United States
Publication date:
2020-10-07
Acceptance date:
2020-08-11
DOI:
ISSN:
2578-5745
Language:
English
Keywords:
Pubs id:
1137030
Local pid:
pubs:1137030
Deposit date:
2020-10-15

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