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Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

Abstract:

Glucagon-like peptide-1 (GLP-1) is an intestinally derived insulinotropic hormone currently under investigation for use as a novel therapeutic agent in the treatment of type 2 diabetes. One of several important effects of GLP-1 is on nutrient-induced pancreatic hormone release and is mediated by binding to a specific G-protein coupled receptor resulting in the activation of adenylate cyclase and an increase in cAMP generation. In the beta-cell, cAMP binds and modulates activities of both prot...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Basic and clinical pharmacology and toxicology More from this journal
Volume:
95
Issue:
6
Pages:
252-262
Publication date:
2004-12-01
DOI:
EISSN:
1742-7843
ISSN:
1742-7835
Language:
English
Keywords:
Pubs id:
pubs:27410
UUID:
uuid:cacfa3dd-7d02-42de-9e6b-c495e3705073
Local pid:
pubs:27410
Source identifiers:
27410
Deposit date:
2012-12-19

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