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Identification of a Plasmodium falciparum intercellular adhesion molecule-1 binding domain: a parasite adhesion trait implicated in cerebral malaria.

Abstract:

Binding of infected erythrocytes to brain venules is a central pathogenic event in the lethal malaria disease complication, cerebral malaria. The only parasite adhesion trait linked to cerebral sequestration is binding to intercellular adhesion molecule-1 (ICAM-1). In this report, we show that Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) binds ICAM-1. We have cloned and expressed PfEMP1 recombinant proteins from the A4tres parasite. Using heterologous expression in mammalian ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.040545897

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
97
Issue:
4
Pages:
1766-1771
Publication date:
2000-02-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424

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