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Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

Abstract:

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%), including four previousl...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pgen.1003500

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
9
Issue:
6
Pages:
e1003500
Publication date:
2013-06-06
Acceptance date:
2013-03-15
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:cac3653e-4da3-4dbd-b346-1d12965b26b5
Source identifiers:
401800
Local pid:
pubs:401800

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