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Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia.

Abstract:

Two distinct groups of chronic lymphocytic leukaemia (CLL) are distinguished by the presence or absence of somatic hypermutation of the immunoglobulin heavy-chain gene. CLL without somatic hypermutation has an adverse outcome, but the precise biological differences that underlie this more aggressive clinical-course are unclear. Using a proteomic approach, we found that the two prognostic forms of CLL were consistently distinguished according to their protein expression pattern. The most impor...

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Publication status:
Published

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Journal:
British journal of haematology More from this journal
Volume:
148
Issue:
4
Pages:
534-543
Publication date:
2010-02-01
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
Language:
English
Keywords:
Pubs id:
pubs:121066
UUID:
uuid:cac12de0-0535-4b2f-9dc0-47bedead7fe7
Local pid:
pubs:121066
Source identifiers:
121066
Deposit date:
2012-12-19

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