Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia.

Journal article

Two distinct groups of chronic lymphocytic leukaemia (CLL) are distinguished by the presence or absence of somatic hypermutation of the immunoglobulin heavy-chain gene. CLL without somatic hypermutation has an adverse outcome, but the precise biological differences that underlie this more aggressive clinical-course are unclear. Using a proteomic approach, we found that the two prognostic forms of CLL were consistently distinguished according to their protein expression pattern. The most impor...

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Authors: Rees-Unwin, K; Faragher, R; Unwin, R; Adams, J; Brown, P

• Publication status: Published
• Journal: British journal of haematology
• Volume: 148
• Issue: 4
• Pages: 534-543
• Publication date: 2010-02-01
• DOI: 10.1111/j.1365-2141.2009.07979.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Gene Expression Regulation, Neoplastic; Up-Regulation; Somatic Hypermutation, Immunoglobulin; DNA Mutational Analysis; Prognosis; Nuclear Proteins; Cell Nucleus; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; DNA, Neoplasm; Neoplasm Proteins; Diagnosis, Differential; Cytoplasm; Tumor Markers, Biological