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Journal article

Allosteric modulation of the calcium-sensing receptor rectifies signaling abnormalities associated with G-protein α-11 mutations causing hypercalcemic and hypocalcemic disorders

Abstract:

Germline loss- and gain-of-function mutations of G-protein α-11 (Gα11), which couples the calcium-sensing receptor (CaSR) to intracellular calcium (Ca2+i) signaling, lead to familial hypocalciuric hypercalcemia type 2 (FHH2) and autosomal dominant hypocalcemia type 2 (ADH2), respectively, whereas somatic Gα11 mutations mediate uveal melanoma development by constitutively up-regulating MAPK signaling. Cinacalcet and NPS-2143 are allosteric CaSR activators and inactivators, respectively, that a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.M115.696401

Authors


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Division:
MSD
Department:
Women's & Reproductive Health
Role:
Author
ORCID:
0000-0002-2975-5170
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Division:
MSD
Department:
RDM
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0002-1361-9174
More by this author
Division:
MSD
Sub department:
Surgical Sciences
Role:
Author
ORCID:
0000-0001-6342-0895
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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of biological chemistry Journal website
Volume:
291
Issue:
20
Pages:
10876-10885
Place of publication:
United States
Publication date:
2016-03-18
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
26994139
Language:
English
Keywords:
Pubs id:
611535
Local pid:
pubs:611535
Deposit date:
2020-03-14

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