Journal article
Allosteric modulation of the calcium-sensing receptor rectifies signaling abnormalities associated with G-protein α-11 mutations causing hypercalcemic and hypocalcemic disorders
- Abstract:
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Germline loss- and gain-of-function mutations of G-protein α-11 (Gα11), which couples the calcium-sensing receptor (CaSR) to intracellular calcium (Ca2+i) signaling, lead to familial hypocalciuric hypercalcemia type 2 (FHH2) and autosomal dominant hypocalcemia type 2 (ADH2), respectively, whereas somatic Gα11 mutations mediate uveal melanoma development by constitutively up-regulating MAPK signaling. Cinacalcet and NPS-2143 are allosteric CaSR activators and inactivators, respectively, that a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, 2.9MB)
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- Publisher copy:
- 10.1074/jbc.M115.696401
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Authors
Funding
Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of biological chemistry Journal website
- Volume:
- 291
- Issue:
- 20
- Pages:
- 10876-10885
- Place of publication:
- United States
- Publication date:
- 2016-03-18
- DOI:
- EISSN:
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1083-351X
- ISSN:
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0021-9258
- Pmid:
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26994139
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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611535
- Local pid:
- pubs:611535
- Deposit date:
- 2020-03-14
Terms of use
- Copyright holder:
- American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2016
- Rights statement:
- © 2016 by The American Society for Biochemistry and Molecular Biology, Inc. Author's Choice—Final version free via Creative Commons CC-BY license.
- Licence:
- CC Attribution (CC BY)
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