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Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells.

Abstract:

Metabolic reprogramming of cancer cells provides energy and multiple intermediates critical for cell growth. Hypoxia in tumors represents a hostile environment that can encourage these transformations. We report that glycogen metabolism is upregulated in tumors in vivo and in cancer cells in vitro in response to hypoxia. In vitro, hypoxia induced an early accumulation of glycogen, followed by a gradual decline. Concordantly, glycogen synthase (GYS1) showed a rapid induction, followed by a lat...

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Publication status:
Published

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Publisher copy:
10.1016/j.cmet.2012.10.017

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Journal:
Cell metabolism
Volume:
16
Issue:
6
Pages:
751-764
Publication date:
2012-12-01
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
Source identifiers:
365543

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