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Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis.

Abstract:

Tuberculosis, one of the leading causes of death worldwide, stimulates inflammatory responses with beneficial and pathologic consequences. The regulation and nature of an optimal inflammatory response to Mycobacterium tuberculosis remains poorly understood in humans. Insight into mechanisms of negative regulation of the TLR-mediated innate immune response to M. tuberculosis could provide significant breakthroughs in the design of new vaccines and drugs. We hypothesized that TOLLIP and its com...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1103541

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
189
Issue:
4
Pages:
1737-1746
Publication date:
2012-08-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:caba4b1e-71c9-443a-8aa8-288985de0d43
Source identifiers:
348817
Local pid:
pubs:348817

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