Journal article
Mathematical modeling reveals the functional implications of the different nuclear shuttling rates of Erk1 and Erk2.
- Abstract:
-
The mitogen-activated protein kinase (MAPK) family of proteins is involved in regulating cellular fates such as proliferation, differentiation and apoptosis. In particular, the dynamics of the Erk/Mek system, which has become the canonical example for MAPK signaling systems, have attracted considerable attention. Erk is encoded by two genes, Erk1 and Erk2, that until recently had been considered equivalent as they differ only subtly at the sequence level. However, these proteins exhibit radic...
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- Publication status:
- Published
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- Publisher copy:
- 10.1088/1478-3975/9/3/036001
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Bibliographic Details
- Journal:
- Physical biology
- Volume:
- 9
- Issue:
- 3
- Pages:
- 036001
- Publication date:
- 2012-06-05
- DOI:
- EISSN:
-
1478-3975
- ISSN:
-
1478-3967
- URN:
-
uuid:cab7155b-d028-4149-89b9-f38d9718d0b8
- Source identifiers:
-
398239
- Local pid:
- pubs:398239
Item Description
Terms of use
- Copyright date:
- 2012
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