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Mathematical modeling reveals the functional implications of the different nuclear shuttling rates of Erk1 and Erk2.

Abstract:

The mitogen-activated protein kinase (MAPK) family of proteins is involved in regulating cellular fates such as proliferation, differentiation and apoptosis. In particular, the dynamics of the Erk/Mek system, which has become the canonical example for MAPK signaling systems, have attracted considerable attention. Erk is encoded by two genes, Erk1 and Erk2, that until recently had been considered equivalent as they differ only subtly at the sequence level. However, these proteins exhibit radic...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Komorowski, M More by this author
Beguerisse-Díaz, M More by this author
Stumpf, MP More by this author
Journal:
Physical biology
Volume:
9
Issue:
3
Pages:
036001
Publication date:
2012-06-05
DOI:
EISSN:
1478-3975
ISSN:
1478-3967
URN:
uuid:cab7155b-d028-4149-89b9-f38d9718d0b8
Source identifiers:
398239
Local pid:
pubs:398239

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