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Thesis

Forward genetic analysis of mammalian immunity

Abstract:

Mutation, whether spontaneous or induced, is the premier tool for understanding gene function. One approach is to create mutations in a specific gene, and then use the resulting cell or organism to search for a phenotype. An alternative is to create mutations at random, and focus first on the identification of phenotypes. The mutation that underlies a phenotype can then be tracked down, forming the foundation of testable hypotheses.

Using random chemical mutagenesis in mice, I have ...

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Institution:
University of Oxford
Division:
MSD
Oxford college:
Lincoln College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
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Name:
General Sir John Monash Foundation
Funding agency for:
Siggs, O
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:caaf6ee7-e2b1-4fe1-a47c-1d6b76b249a4
Local pid:
ora:9796
Deposit date:
2015-01-23

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