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Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies.

Abstract:

We have probed the structures of monomeric and oligomeric gp120 glycoproteins from the LAI isolate of human immunodeficiency virus type 1 (HIV-1) with a panel of monoclonal antibodies (MAbs); most of these MAbs are directed against continuous epitopes. On native monomeric gp120, most of the first conserved (C1) domain is accessible to MAbs, although some regions of C1 are relatively inaccessible. All of the MAbs directed against the C2, C3, and C5 domains bind preferentially to denatured mono...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
Journal of virology More from this journal
Volume:
68
Issue:
1
Pages:
469-484
Publication date:
1994-01-01
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:20306
UUID:
uuid:caaaf7b8-7bd9-49ee-8381-a9f8cf828faa
Local pid:
pubs:20306
Source identifiers:
20306
Deposit date:
2012-12-19

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