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Multi-loop model of Alzheimer disease: an integrated perspective on the Wnt/GSK3β, α-Synuclein, and type 3 diabetes hypotheses

Abstract:

As the prevalence of Alzheimer disease (AD) continues to rise unabated, new models have been put forth to improve our understanding of this devastating condition. Although individual models may have their merits, integrated models may prove more valuable. Indeed, the reliable failures of monotherapies for AD, and the ensuing surrender of major drug companies, suggests that an integrated perspective may be necessary if we are to invent multifaceted treatments that could ultimately prove more s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fnagi.2019.00184

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Merton College
Role:
Author
ORCID:
0000-0002-3237-7553
Publisher:
Frontiers Media
Journal:
Frontiers in Aging Neuroscience More from this journal
Volume:
11
Issue:
JUL
Article number:
184
Publication date:
2019-07-31
Acceptance date:
2019-07-05
DOI:
EISSN:
1663-4365
ISSN:
1663-4365
Pmid:
31417394
Language:
English
Keywords:
Pubs id:
1046711
Local pid:
pubs:1046711
Deposit date:
2020-06-15

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