A Model of the Spatially Dependent Mechanical Properties of the Axon During Its Growth

Journal article

Neuronal growth is a complex process involving many intra- and extracellular mechanisms which are collaborating conjointly to participate to the development of the nervous system. More particularly, the early neocortical development involves the creation of a multilayered structure constituted by neuronal growth (driven by axonal or dendritic guidance cues) as well as cell migration. The underlying mechanisms of such structural lamination not only implies important biochemical changes at the ...

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Authors: Garcia, J; Pena, J; McHugh, S; Jerusalem, A

• Publication status: Published
• Journal: CMES-COMPUTER MODELING IN ENGINEERING and SCIENCES
• Volume: 87
• Issue: 5
• Pages: 411-432
• Publication date: 2012-10-01
• ISSN: 1526-1492
• Language: English
• Keywords: mechanical properties; axonal growth; Microtubule polymerization; finite difference modeling