Journal article
Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.
- Abstract:
-
BACKGROUND: Obesity is highly associated with elevated serum triglycerides, hepatic steatosis and type 2 diabetes (T2D). The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis. No association between PNPLA3 I148M genotype and T2D in Europeans has been reported. Aim of this study is to examine the relationship between PNPLA3 I148M genotypes and serum triglycerides, insulin...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 702.5KB)
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- Publisher copy:
- 10.1371/journal.pone.0039362
Authors
Funding
UK Medical Research Council (G0601261)
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Chief Scientist Office of Scotland
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Wellcome Trust
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Institute of Medicine at the University of Gothenburg
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Swedish Federal Government
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 7
- Issue:
- 6
- Article number:
- e39362
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:ca9c1bf2-605e-45e5-8d92-c72e1ac41e42
- Local pid:
- pubs:341373
- Source identifiers:
-
341373
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Palmer et al
- Copyright date:
- 2012
- Notes:
- Copyright 2012 Palmer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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