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Transcriptomics in human challenge models

Abstract:

Human challenge models, in which volunteers are experimentally infected with a pathogen of interest, provide the opportunity to directly identify both natural and vaccine-induced correlates of protection. In this review, we highlight how the applica tion of transcriptomics to human challenge studies allows for the identification of novel correlates and gives insight into the immunological pathways required to develop functional immunity. In malaria challenge trials for example, innate immune ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2017.01839

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Oxford college:
St Cross College
Role:
Author
ORCID:
0000-0001-7361-719X
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Role:
Author
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Funding agency for:
Barton, A
Grant:
St Cross Paediatrics Scholarship
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Funding agency for:
Hill, J
Grant:
George
SusanBrownlee Fellowship
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Grant:
Oxford Biomedical Research Centre
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Grant:
Strategic Award no. 106158/Z/14/Z
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
8
Issue:
DEC
Article number:
1839
Publication date:
2017-12-18
Acceptance date:
2017-12-05
DOI:
ISSN:
1664-3224
Source identifiers:
812780
Keywords:
Pubs id:
pubs:812780
UUID:
uuid:ca98e488-162c-4cbf-a2be-6985bfce9ae5
Local pid:
pubs:812780
Deposit date:
2017-12-25

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