The role of receptors for tumour necrosis factor-alpha in the induction of human polymorphonuclear neutrophil chemiluminescence.

Journal article

Tumour necrosis factor-alpha (TNF-alpha) is a potent mediator of inflammation, which exerts profound effects on polymorphonuclear neutrophils (PMN). TNF-alpha binds to distinct cell surface receptors termed p55 and p75, expressed in approximately equal amounts on the PMN surface. We have studied the effects of TNF-alpha on the priming of F-Met-Leu-Phe (FMLP)-stimulated oxidative metabolism of PMN, using a luminol-enhanced chemiluminescence assay, and have examined the relative roles of PMN re...

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Authors: Zeman, K; Kantorski, J; Paleolog, E; Feldmann, M; Tchórzewski, H

• Publication status: Published
• Journal: Immunology letters
• Volume: 53
• Issue: 1
• Pages: 45-50
• Publication date: 1996-10-01
• DOI: 10.1016/0165-2478(96)02613-2
• EISSN: 1879-0542
• ISSN: 0165-2478
• Language: English
• Keywords: Receptors, Tumor Necrosis Factor, Type II; Neutrophils; Luminol; Antibodies, Monoclonal; Humans; Respiratory Burst; Indicators and Reagents; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Tumor Necrosis Factor-alpha; Antigens, CD; Receptors, Tumor Necrosis Factor, Type I; N-Formylmethionine Leucyl-Phenylalanine; Adult; Chemiluminescent Measurements