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Journal article

CD28 costimulatory signal induces protein arginine methylation in T cells.

Abstract:

Protein phosphorylation initiates signal transduction that triggers lymphocyte activation. However, other posttranslational modifications may contribute to this process. Here, we show that CD28 engagement induced protein arginine methyltransferase activity and methylation on arginine of several proteins, including Vav1. Methylation of Vav1 and IL-2 production were reduced by inhibiting S-adenosyl-L-homocysteine hydrolase, an enzyme that regulates cellular transmethylation. Methylated Vav1 was...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20050176

Authors


Blanchet, F More by this author
Cardona, A More by this author
Letimier, FA More by this author
Hershfield, MS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
The Journal of experimental medicine
Volume:
202
Issue:
3
Pages:
371-377
Publication date:
2005-08-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:ca95fc17-6a0d-4fd3-a70c-b1191e66471a
Source identifiers:
21534
Local pid:
pubs:21534

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