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Journal article

Mouse knockout models for HIV-1 restriction factors.

Abstract:

Infection of cells with human immunodeficiency virus 1 (HIV-1) is controlled by restriction factors, host proteins that counteract a variety of steps in the life cycle of this lentivirus. These include SAMHD1, APOBEC3G and tetherin, which block reverse transcription, hypermutate viral DNA and prevent progeny virus release, respectively. These and other HIV-1 restriction factors are conserved and have clear orthologues in the mouse. This review summarises studies in knockout mice lacking HIV-1...

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Publication status:
Published

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Publisher copy:
10.1007/s00018-014-1646-8

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Cellular and molecular life sciences : CMLS More from this journal
Volume:
71
Issue:
19
Pages:
3749-3766
Publication date:
2014-10-01
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
Language:
English
Keywords:
Pubs id:
pubs:466202
UUID:
uuid:ca90f9b2-b942-4e7d-bdc6-fdea0dfc39f8
Local pid:
pubs:466202
Source identifiers:
466202
Deposit date:
2014-07-16

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