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Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo.

Abstract:

Although recognition of lipopolysaccharide (LPS) by the myeloid differentiation factor 2-Toll-like receptor 4 complex is important for triggering protective inflammatory responses in animals, terminating many of these responses requires LPS inactivation by a host lipase, acyloxyacyl hydrolase (AOAH). To test whether endogenously produced recombinant AOAH can modulate responses to LPS and gram-negative bacteria, we engineered transgenic mice that overexpress AOAH in dendritic cells and macroph...

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Publication status:
Published

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Publisher copy:
10.1086/646616

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Munford, RS More by this author
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Journal:
The Journal of infectious diseases
Volume:
200
Issue:
11
Pages:
1685-1693
Publication date:
2009-12-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:ca8d1822-4577-488f-9271-787a4e73a70d
Source identifiers:
7119
Local pid:
pubs:7119

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