- Abstract:
-
Isoniazid (INH, isonicotinic acid hydrazine) is one of only two therapeutic agents effective in treating tuberculosis. This prodrug is activated by the heme enzyme catalase peroxidase (KatG) endogenous to Mycobacterium tuberculosis but the mechanism of activation is poorly understood, in part because the binding interaction has not been properly established. The class I peroxidases ascorbate peroxidase (APX) and cytochrome c peroxidase (CcP) have active site structures very similar to KatG an...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m707412200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 283
- Issue:
- 10
- Pages:
- 6193-6200
- Publication date:
- 2008-03-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:ca83589e-71ba-4cf0-a097-688a99de0e28
- Source identifiers:
-
240691
- Local pid:
- pubs:240691
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
The tuberculosis prodrug isoniazid bound to activating peroxidases.
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