Journal article
The tuberculosis prodrug isoniazid bound to activating peroxidases.
- Abstract:
-
Isoniazid (INH, isonicotinic acid hydrazine) is one of only two therapeutic agents effective in treating tuberculosis. This prodrug is activated by the heme enzyme catalase peroxidase (KatG) endogenous to Mycobacterium tuberculosis but the mechanism of activation is poorly understood, in part because the binding interaction has not been properly established. The class I peroxidases ascorbate peroxidase (APX) and cytochrome c peroxidase (CcP) have active site structures very similar to KatG an...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m707412200
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Authors
Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 283
- Issue:
- 10
- Pages:
- 6193-6200
- Publication date:
- 2008-03-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
240691
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:240691
- UUID:
-
uuid:ca83589e-71ba-4cf0-a097-688a99de0e28
- Local pid:
- pubs:240691
- Deposit date:
- 2013-02-20
Terms of use
- Copyright date:
- 2008
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