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Journal article

The tuberculosis prodrug isoniazid bound to activating peroxidases.

Abstract:

Isoniazid (INH, isonicotinic acid hydrazine) is one of only two therapeutic agents effective in treating tuberculosis. This prodrug is activated by the heme enzyme catalase peroxidase (KatG) endogenous to Mycobacterium tuberculosis but the mechanism of activation is poorly understood, in part because the binding interaction has not been properly established. The class I peroxidases ascorbate peroxidase (APX) and cytochrome c peroxidase (CcP) have active site structures very similar to KatG an...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m707412200

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
The Journal of biological chemistry
Volume:
283
Issue:
10
Pages:
6193-6200
Publication date:
2008-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:ca83589e-71ba-4cf0-a097-688a99de0e28
Source identifiers:
240691
Local pid:
pubs:240691

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