Journal article
Interventions targeting glucocorticoid-Krüppel-like factor 15-branched-chain amino acid signaling improve disease phenotypes in spinal muscular atrophy mice
- Abstract:
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The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is a neuromuscular disorder also characterized by intrinsic muscle pathologies, metabolic abnormalities and disrupted sleep patterns, which can influence or be influenced by circadian regulatory networks that control behavioral and metabolic rhythms. ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.9MB)
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- Publisher copy:
- 10.1016/j.ebiom.2018.04.024
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Authors
Funding
Gwendolyn Strong Foundation
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SMA Angels Charity
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SMA Trust
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French Muscular Dystrophy Association
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Families of SMA Canada
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- EBioMedicine Journal website
- Volume:
- 31
- Pages:
- 226-242
- Publication date:
- 2018-05-04
- Acceptance date:
- 2018-04-26
- DOI:
- EISSN:
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2352-3964
- ISSN:
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2352-3964
- Pmid:
-
29735415
- Source identifiers:
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847086
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:847086
- UUID:
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uuid:ca7cad50-99e5-46e9-9c9d-4f7056488493
- Local pid:
- pubs:847086
- Deposit date:
- 2018-07-31
Terms of use
- Copyright holder:
- Bowerman et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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