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Journal article

Interventions targeting glucocorticoid-Krüppel-like factor 15-branched-chain amino acid signaling improve disease phenotypes in spinal muscular atrophy mice

Abstract:

The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is a neuromuscular disorder also characterized by intrinsic muscle pathologies, metabolic abnormalities and disrupted sleep patterns, which can influence or be influenced by circadian regulatory networks that control behavioral and metabolic rhythms. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ebiom.2018.04.024

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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SMA Angels Charity More from this funder
Gwendolyn Strong Foundation More from this funder
French Muscular Dystrophy Association More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
31
Pages:
226-242
Publication date:
2018-05-04
Acceptance date:
2018-04-26
DOI:
EISSN:
2352-3964
ISSN:
2352-3964
Pubs id:
pubs:847086
URN:
uri:ca7cad50-99e5-46e9-9c9d-4f7056488493
UUID:
uuid:ca7cad50-99e5-46e9-9c9d-4f7056488493
Local pid:
pubs:847086

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