- Abstract:
-
The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is a neuromuscular disorder also characterized by intrinsic muscle pathologies, metabolic abnormalities and disrupted sleep patterns, which can influence or be influenced by circadian regulatory networks that control behavioral and metabolic rhythms. ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.9MB)
-
- Publisher copy:
- 10.1016/j.ebiom.2018.04.024
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- EBioMedicine Journal website
- Volume:
- 31
- Pages:
- 226-242
- Publication date:
- 2018-05-04
- Acceptance date:
- 2018-04-26
- DOI:
- EISSN:
-
2352-3964
- ISSN:
-
2352-3964
- Pubs id:
-
pubs:847086
- URN:
-
uri:ca7cad50-99e5-46e9-9c9d-4f7056488493
- UUID:
-
uuid:ca7cad50-99e5-46e9-9c9d-4f7056488493
- Local pid:
- pubs:847086
- Language:
- English
- Keywords:
- Copyright holder:
- Bowerman et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Journal article
Interventions targeting glucocorticoid-Krüppel-like factor 15-branched-chain amino acid signaling improve disease phenotypes in spinal muscular atrophy mice
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SMA Trust
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SMA Angels Charity
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Gwendolyn Strong Foundation
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FightSMA
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French Muscular Dystrophy Association
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