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Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken.

Abstract:

Sporadic inclusion body myositis (sIBM) is the most frequently acquired myopathy in patients over 50 years of age. It is imperative that neurologists and rheumatologists recognize this disorder which may, through clinical and pathological similarities, mimic other myopathies, especially polymyositis. Whereas polymyositis responds to immunosuppressant drug therapy, sIBM responds poorly, if at all. Controversy reigns as to whether sIBM is primarily an inflammatory or a degenerative myopathy, th...

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Publisher copy:
10.1007/s00401-015-1384-5

Authors


Benveniste, O More by this author
Stenzel, W More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Acta Neuropathol
Publication date:
2015-01-13
DOI:
EISSN:
1432-0533
URN:
uuid:ca75ed85-c0ce-424a-84d1-c0d386f4d25f
Source identifiers:
503349
Local pid:
pubs:503349
Language:
English

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