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Automated solid-phase extraction method for the determination of atovaquone in capillary blood applied onto sampling paper by rapid high-performance liquid chromatography.

Abstract:

A bioanalytical method for the determination of atovaquone in 100 microl blood-spots by solid-phase extraction and high-performance liquid chromatography has been developed and validated. Atovaquone was extracted from the sampling paper in 0.2 M phosphoric acid and a structurally similar internal standard was added with acetonitrile before being loaded onto a C8 end-capped solid-phase extraction column. Atovaquone and internal standard were analysed by high-performance liquid chromatography o...

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Publication status:
Published

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Journal:
Journal of chromatography. B, Biomedical sciences and applications More from this journal
Volume:
758
Issue:
2
Pages:
137-144
Publication date:
2001-07-01
DOI:
ISSN:
1387-2273
Language:
English
Keywords:
Pubs id:
pubs:1013
UUID:
uuid:ca73c6b1-fbdf-4f2e-820b-388ac66a4e1a
Local pid:
pubs:1013
Source identifiers:
1013
Deposit date:
2012-12-19

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