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Traceless rhodium-catalyzed hydroacylation using alkyl aldehydes: the enantioselective synthesis of β-aryl ketones

Abstract:
A one-pot three-step sequence involving Rh-catalyzed alkene hydroacylation, sulfide elimination and Rh-catalyzed aryl boronic acid conjugate addition, delivers products of traceless chelation-controlled hydroacylation employing alkyl aldehydes. The stereodefined β-aryl ketones are obtained in good yields with excellent control of enantioselectivity. Good variation of all three reaction components is possible.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/chem.201604035

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Grant:
(FP7/2007-2013) Grant 316955
Engineering and Physical Sciences Research Council More from this funder
Publisher:
Wiley Publisher's website
Journal:
Chemistry: A European Journal Journal website
Volume:
22
Issue:
44
Pages:
15624–15628
Publication date:
2016-09-26
Acceptance date:
2016-08-26
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Pubs id:
pubs:641020
URN:
uri:ca63d717-38bc-46b9-a7f8-76405cd42c26
UUID:
uuid:ca63d717-38bc-46b9-a7f8-76405cd42c26
Local pid:
pubs:641020

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