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Structure of hen egg-white lysozyme solvated in TFE/water: a molecular dynamics simulation study based on NMR data.

Abstract:

Various experimental studies of hen egg white lysozyme (HEWL) in water and TFE/water clearly indicate structural differences between the native state and TFE state of HEWL, e.g. the helical content of the protein in the TFE state is much higher than in the native state. However, the available detailed NMR studies were not sufficient to determine fully a structure of HEWL in the TFE state. Different molecular dynamics (MD) simulations, i.e. at room temperature, at increased temperature and usi...

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Publication status:
Published

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Publisher copy:
10.1007/s10858-013-9717-y

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
Journal:
Journal of biomolecular NMR More from this journal
Volume:
55
Issue:
4
Pages:
339-353
Publication date:
2013-04-01
DOI:
EISSN:
1573-5001
ISSN:
0925-2738
Language:
English
Keywords:
Pubs id:
pubs:405205
UUID:
uuid:ca5fc061-b85e-4258-9497-ead626ca4128
Local pid:
pubs:405205
Source identifiers:
405205
Deposit date:
2013-11-17

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