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Human IL-6RhiTIGIT− CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile

Abstract:

To date many clinical studies aim to increase the number and/or fitness of CD4+CD127lowCD25+ regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of treating autoimmune disease. Here, we sought to define the phenotype and function of Tregs expressing the highest levels of IL-6 receptor (IL-6R). We have identified a population of CD4+CD127lowCD25+ TIGIT− T cells distinguished by their elevated IL-6R expression that lacked expression of HELIOS, showed higher ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.clim.2017.03.002

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
JDRF
Grant:
9-2011-253/5-SRA-2015-130-A-N/
2-APF-2017-420-A-N/JDRF
More from this funder
Name:
Wellcome Trust
Grant:
WT091157/107212
WT083650/Z/07/Z/
Publisher:
Elsevier
Journal:
Clinical Immunology More from this journal
Volume:
179
Pages:
25-39
Publication date:
2017-03-09
Acceptance date:
2017-03-07
DOI:
EISSN:
1521-7035
ISSN:
1521-6616
Keywords:
Pubs id:
pubs:685481
UUID:
uuid:ca5d7eda-b0dd-4649-8ff1-6338cdbdcbd8
Local pid:
pubs:685481
Deposit date:
2017-03-13

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