Journal article
Human IL-6RhiTIGIT− CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile
- Abstract:
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To date many clinical studies aim to increase the number and/or fitness of CD4+CD127lowCD25+ regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of treating autoimmune disease. Here, we sought to define the phenotype and function of Tregs expressing the highest levels of IL-6 receptor (IL-6R). We have identified a population of CD4+CD127lowCD25+ TIGIT− T cells distinguished by their elevated IL-6R expression that lacked expression of HELIOS, showed higher ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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(pdf, 2.6MB)
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- Publisher copy:
- 10.1016/j.clim.2017.03.002
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Clinical Immunology Journal website
- Volume:
- 179
- Pages:
- 25-39
- Publication date:
- 2017-03-09
- Acceptance date:
- 2017-03-07
- DOI:
- EISSN:
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1521-7035
- ISSN:
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1521-6616
- Pubs id:
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pubs:685481
- URN:
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uri:ca5d7eda-b0dd-4649-8ff1-6338cdbdcbd8
- UUID:
-
uuid:ca5d7eda-b0dd-4649-8ff1-6338cdbdcbd8
- Local pid:
- pubs:685481
Item Description
- Keywords:
Terms of use
- Copyright holder:
- Ferreira et al.
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by Elsevier Inc. Open Access funded by Wellcome Trust available under a Creative Commons license.
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