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Human IL-6RhiTIGIT− CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile

Abstract:

To date many clinical studies aim to increase the number and/or fitness of CD4+CD127lowCD25+ regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of treating autoimmune disease. Here, we sought to define the phenotype and function of Tregs expressing the highest levels of IL-6 receptor (IL-6R). We have identified a population of CD4+CD127lowCD25+ TIGIT− T cells distinguished by their elevated IL-6R expression that lacked expression of HELIOS, showed higher ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.clim.2017.03.002

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Grant:
WT091157/107212; WT083650/Z/07/Z/
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Grant:
9-2011-253/5-SRA-2015-130-A-N/; 2-APF-2017-420-A-N/JDRF
Publisher:
Elsevier Publisher's website
Journal:
Clinical Immunology Journal website
Volume:
179
Pages:
25-39
Publication date:
2017-03-09
Acceptance date:
2017-03-07
DOI:
EISSN:
1521-7035
ISSN:
1521-6616
Pubs id:
pubs:685481
URN:
uri:ca5d7eda-b0dd-4649-8ff1-6338cdbdcbd8
UUID:
uuid:ca5d7eda-b0dd-4649-8ff1-6338cdbdcbd8
Local pid:
pubs:685481
Keywords:

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