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Tumour-stromal interactions in acid-mediated invasion: a mathematical model.

Abstract:

It is well established that the tumour microenvironment can both promote and suppress tumour growth and invasion, however, most mathematical models of invasion view the normal tissue as inhibiting tumour progression via immune modulation or spatial constraint. In particular, the production of acid by tumour cells and the subsequent creation of a low extracellular pH environment has been explored in several 'acid-mediated tumour invasion' models where the acidic environment facilitates normal ...

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Publication status:
Published

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Publisher copy:
10.1016/j.jtbi.2010.08.028

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Journal of theoretical biology
Volume:
267
Issue:
3
Pages:
461-470
Publication date:
2010-12-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:ca54c7b2-0ba9-4163-97c9-98328174784f
Source identifiers:
71159
Local pid:
pubs:71159

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