- Abstract:
-
It is well established that the tumour microenvironment can both promote and suppress tumour growth and invasion, however, most mathematical models of invasion view the normal tissue as inhibiting tumour progression via immune modulation or spatial constraint. In particular, the production of acid by tumour cells and the subsequent creation of a low extracellular pH environment has been explored in several 'acid-mediated tumour invasion' models where the acidic environment facilitates normal ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jtbi.2010.08.028
-
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- Journal:
- Journal of theoretical biology
- Volume:
- 267
- Issue:
- 3
- Pages:
- 461-470
- Publication date:
- 2010-12-05
- DOI:
- EISSN:
-
1095-8541
- ISSN:
-
0022-5193
- URN:
-
uuid:ca54c7b2-0ba9-4163-97c9-98328174784f
- Source identifiers:
-
71159
- Local pid:
- pubs:71159
- Copyright date:
- 2010
Journal article
Tumour-stromal interactions in acid-mediated invasion: a mathematical model.
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