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Journal article

Telomere length and genetics are independent colorectal tumour risk factors in an evaluation of biomarkers in normal bowel.

Abstract:

Background

Colorectal cancer (CRC) screening might be improved by using a measure of prior risk to modulate screening intensity or the faecal immunochemical test threshold. Intermediate molecular biomarkers could aid risk prediction by capturing both known and unknown risk factors.

Methods

We sampled normal bowel mucosa from the proximal colon, distal colon and rectum of 317 individuals undergoing colonoscopy. We defined cases as having a personal history of color...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1038/bjc.2017.486

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care; Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Oxford Ludwig Institute
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
090532/Z/09/Z
More from this funder
Name:
European Collaboration in Science and Technology
More from this funder
Name:
Marie Sklodowska-Curie Intra-European Fellowship Action
Publisher:
Nature Publishing Group
Journal:
British Journal of Cancer More from this journal
Volume:
118
Issue:
6
Pages:
727–732
Publication date:
2018-02-01
Acceptance date:
2017-12-13
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Pmid:
29438375
Language:
English
Keywords:
Pubs id:
pubs:825091
UUID:
uuid:ca542530-c62e-4dfd-836d-a89119fc88f2
Local pid:
pubs:825091
Source identifiers:
825091
Deposit date:
2018-02-19

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