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Journal article

No evidence for drug resistance by iminosugar-based HCV assembly inhibitors in tissue culture

Abstract:

At present, neither a selective antiviral therapy nor a vaccine is available for HCV, and the current treatment is only effective in a fraction of patients. Given the recent demonstration that antiviral compounds targeting the NS5B polymerase and the NS3/4A protease lead to rapid selection for resistance, iminosugar derivatives as HCV assembly inhibitors were characterized for drug resistance. It has been previously shown that deoxynojirimycin (DNJ)-containing iminosugars are potent HCV antiv...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Steinmann, E More by this author
Friesland, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Pietschmann, T More by this author
Publisher:
Elsevier Publisher's website
Journal:
Journal of Hepatology Journal website
Volume:
52
Pages:
S261-S262
Publication date:
2010
DOI:
ISSN:
0168-8278
URN:
uuid:ca51c17f-8eb1-473e-bd27-7bf46cd1b6c7
Source identifiers:
100734
Local pid:
pubs:100734

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