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Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium.

Abstract:

RATIONALE: The Slit-Roundabout (Robo) signaling pathway has pleiotropic functions during Drosophila heart development. However, its role in mammalian heart development is largely unknown. OBJECTIVE: To analyze the role of Slit-Robo signaling in the formation of the pericardium and the systemic venous return in the murine heart. METHODS AND RESULTS: Expression of genes encoding Robo1 and Robo2 receptors and their ligands Slit2 and Slit3 was found in or around the systemic venous return and pe...

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Authors


Mommersteeg, MT More by this author
Andrews, WD More by this author
Ypsilanti, AR More by this author
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Journal:
Circulation research
Volume:
112
Issue:
3
Pages:
465-475
Publication date:
2013-02-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:ca513d48-dd6a-4498-b0dc-60b03429f3bc
Source identifiers:
482159
Local pid:
pubs:482159

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