- Abstract:
-
RATIONALE: The Slit-Roundabout (Robo) signaling pathway has pleiotropic functions during Drosophila heart development. However, its role in mammalian heart development is largely unknown. OBJECTIVE: To analyze the role of Slit-Robo signaling in the formation of the pericardium and the systemic venous return in the murine heart. METHODS AND RESULTS: Expression of genes encoding Robo1 and Robo2 receptors and their ligands Slit2 and Slit3 was found in or around the systemic venous return and pe...
Expand abstract - Publisher copy:
- 10.1161/circresaha.112.277426
-
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- Journal:
- Circulation research
- Volume:
- 112
- Issue:
- 3
- Pages:
- 465-475
- Publication date:
- 2013-02-05
- DOI:
- EISSN:
-
1524-4571
- ISSN:
-
0009-7330
- URN:
-
uuid:ca513d48-dd6a-4498-b0dc-60b03429f3bc
- Source identifiers:
-
482159
- Local pid:
- pubs:482159
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium.
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