Common and rare variants in multifactorial susceptibility to common diseases.

Journal article

Here, we give a historical overview of the search for genetic variants that influence the susceptibility of an individual to a chronic disease, from RA Fisher's seminal work to the current excitement of whole-genome association studies (WGAS). We then discuss the concepts behind the identification of common variants as disease causal factors and contrast them to the basic ideas that underlie the rare variant hypothesis. The identification of rare variants involves the careful selection of can...

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Authors: Bodmer, W; Bonilla, C

• Publication status: Published
• Journal: Nature genetics
• Volume: 40
• Issue: 6
• Pages: 695-701
• Publication date: 2008-06-01
• DOI: 10.1038/ng.f.136
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Genetic Variation; Humans; Multifactorial Inheritance; Disease Susceptibility; Genetic Linkage; Quantitative Trait, Heritable