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Common and rare variants in multifactorial susceptibility to common diseases.

Abstract:

Here, we give a historical overview of the search for genetic variants that influence the susceptibility of an individual to a chronic disease, from RA Fisher's seminal work to the current excitement of whole-genome association studies (WGAS). We then discuss the concepts behind the identification of common variants as disease causal factors and contrast them to the basic ideas that underlie the rare variant hypothesis. The identification of rare variants involves the careful selection of can...

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Publication status:
Published

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Publisher copy:
10.1038/ng.f.136

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Weatherall Insti. of Molecular Medicine
Bonilla, C More by this author
Journal:
Nature genetics
Volume:
40
Issue:
6
Pages:
695-701
Publication date:
2008-06-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:ca4ef0a4-ebf2-43e4-b7f6-d78f52e4532b
Source identifiers:
175133
Local pid:
pubs:175133

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