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Protein phosphatase 1 and memory: practice makes PP1 imperfect?

Abstract:
Long-lasting memories are most efficiently formed by multiple training sessions separated by appropriately timed intervals. A recent study revealed that expression of a transgene encoding an inhibitor of protein phosphatase 1 (PP1) in the forebrain enhanced memory formed during sub-optimal training. Thus, PP1 apparently constrains memory formation in the mouse. Furthermore, the report proposes that PP1 promotes forgetting.

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Trends in neurosciences More from this journal
Volume:
26
Issue:
3
Pages:
117-119
Publication date:
2003-03-01
DOI:
EISSN:
1878-108X
ISSN:
0166-2236
Language:
English
Keywords:
Pubs id:
pubs:252414
UUID:
uuid:ca45ffec-d7da-4f6e-b5b8-6ce36c0c22c5
Local pid:
pubs:252414
Source identifiers:
252414
Deposit date:
2012-12-19

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