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Intracellular antibodies and cancer: new technologies offer therapeutic opportunities.

Abstract:

Since the realisation that the antigen-binding regions of antibodies, the variable (V) regions, can be uncoupled from the rest of the molecule to create fragments that recognise and abrogate particular protein functions in cells, the use of antibody fragments inside cells has become an important tool in bioscience. Diverse libraries of antibody fragments plus in vivo screening can be used to isolate single chain variable fragments comprising VH and VL segments or single V-region domains. Some...

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Publisher copy:
10.1002/bies.201000009

Authors


Pérez-Martínez, D More by this author
Rabbitts, TH More by this author
Journal:
BioEssays : news and reviews in molecular, cellular and developmental biology
Volume:
32
Issue:
7
Pages:
589-598
Publication date:
2010-07-05
DOI:
EISSN:
1521-1878
ISSN:
0265-9247
URN:
uuid:ca44c082-6151-4f73-8434-201eec09c081
Source identifiers:
324309
Local pid:
pubs:324309

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