Journal article
Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors.
- Abstract:
-
Varicella zoster viru (VZV)-specific T cell responses are believed to be vital in recovery from primary VZV infection and also in the prevention of viral reactivation. While glycoprotein E (gE) is the most abundant and one of the most immunogenic proteins of the virus, there are no data addressing potential T cell epitopes within gE, nor the phenotype of specific T cells. Using interferon gamma enzyme-linked immunospot assays and intracellular cytokine assays, we identified gE-specific immune...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Clinical and experimental immunology
- Volume:
- 152
- Issue:
- 3
- Pages:
- 522-531
- Publication date:
- 2008-06-01
- DOI:
- EISSN:
-
1365-2249
- ISSN:
-
0009-9104
- Source identifiers:
-
13406
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:13406
- UUID:
-
uuid:ca3bb9f6-acc6-4813-ad3d-6701e96ef773
- Local pid:
- pubs:13406
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2008
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