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Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors.

Abstract:

Varicella zoster viru (VZV)-specific T cell responses are believed to be vital in recovery from primary VZV infection and also in the prevention of viral reactivation. While glycoprotein E (gE) is the most abundant and one of the most immunogenic proteins of the virus, there are no data addressing potential T cell epitopes within gE, nor the phenotype of specific T cells. Using interferon gamma enzyme-linked immunospot assays and intracellular cytokine assays, we identified gE-specific immune...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-CTU
Role:
Author
Journal:
Clinical and experimental immunology
Volume:
152
Issue:
3
Pages:
522-531
Publication date:
2008-06-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:ca3bb9f6-acc6-4813-ad3d-6701e96ef773
Source identifiers:
13406
Local pid:
pubs:13406

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